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KMID : 1188320130070050519
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Gut and Liver
2013 Volume.7 No. 5 p.519 ~ p.523
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Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms
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Kim Eun-Ran
Yang Mun-Hee
Lim Yeun-Jung
Lee Jin-Hee
Chang Dong-Kyung
Kim Young-Ho
Son Hee-Jung
Kim Jae-J
Rhee Jong-Chul
Kim Jin-Yong
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Abstract
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Background/Aims:Plasminogen activator inhibitor-1 (PAI-1) is important for tumor growth, Invasion, and metastasis. In this study, we investigated the relationship between plasma levels of PAI-1 and colorectal adenomas.
Methods:We reviewed the medical records of 3,136 subjects who underwent colonoscopy as a screening exam. The subjects were classified into a case group with adenomas (n=990) and a control group (n=2,146). Plasma PAI-1 levels were categorized into three groups based on tertile.
Results:The plasma levels of PAI-1 were significantly higher in adenoma cases than in controls (p=0.023). The prevalence of colorectal adenomas increased significantly with increasing levels of PAI-1 (p=0.038). In the adenoma group, advanced pathologic features, size, and number of adenomas did not differ among the three groups based on tertiles for plasma PAI-1 levels. Using multivariate analysis, we found that plasma level of PAI-1 was not associated with the risk of colorectal adenomas (p=0.675). Adjusted odds ratios for colorectal adenomas according to increasing plasma levels of PAI-1 were 0.980 (95% confidence interval [CI], 0.768 to 1.251) for the second-highest plasma level and 1.091 (95% CI, 0.898 to 1.326) for the highest level, compared with the lowest levels.
Conclusions:These results suggest that elevated plasma PAI-1 levels are not associated with the risk of colorectal neoplasms.
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KEYWORD
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Plasminogen activator inhibitor 1, Colorectal neoplasms
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